Invention Grant
- Patent Title: Humanized antibodies against the beta-amyloid peptide
- Patent Title (中): 针对β-淀粉样肽的人源化抗体
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Application No.: US13667723Application Date: 2012-11-02
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Publication No.: US09273126B2Publication Date: 2016-03-01
- Inventor: Stefan Ewert , Adrian Auf Der Maur , Susann Cattepoel , Roger Nitsch
- Applicant: Stefan Ewert , Adrian Auf Der Maur , Susann Cattepoel , Roger Nitsch
- Applicant Address: CH Schlieren CH Zürich
- Assignee: Delenex Therapeutics AG,University of Zurich
- Current Assignee: Delenex Therapeutics AG,University of Zurich
- Current Assignee Address: CH Schlieren CH Zürich
- Agency: Lathrop & Gage LLP
- Agent James H. Velema; Andrew T. Wilkins
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C07K16/18 ; A61K39/395 ; A61K39/00
Abstract:
The invention discloses an isolated antibody that selectively binds to the C-terminal part of Abeta and is humanized or fully human. The antibody of the invention is capable of preventing oligomerization of Abeta. Furthermore, a method of diagnosis comprising the steps of: (i) Labelling an antibody; (ii) Administering an effective dose of said antibody intranasally or systemically to a subject; and (iii) Detecting the concentration and/or presence of the labelled antibody in body parts of the subject is disclosed.
Public/Granted literature
- US20130345292A1 HUMANIZED ANTIBODIES AGAINST THE BETA-AMYLOID PEPTIDE Public/Granted day:2013-12-26
Information query
