Invention Grant
- Patent Title: Gene inactivated mutants with altered protein production
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Application No.: US14217904Application Date: 2014-03-18
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Publication No.: US09273279B2Publication Date: 2016-03-01
- Inventor: Huaming Wang
- Applicant: Danisco US Inc.
- Applicant Address: US CA Palo Alto
- Assignee: Danisco US Inc.
- Current Assignee: Danisco US Inc.
- Current Assignee Address: US CA Palo Alto
- Agency: Danisco US Inc.
- Main IPC: C12P21/00
- IPC: C12P21/00 ; C12N1/14 ; C12N9/02 ; C12N9/48 ; C12N9/62 ; C12N9/88 ; C12N15/52 ; C12P21/02
Abstract:
A recombinant filamentous fungal cell (e.g. Aspergillus) having one or more inactivated chromosomal genes is provided. The chromosomal genes in some embodiments correspond to derA, derB, htmA, mnn9, mnn10, ochA, dpp4, dpp5, pepAa, pepAb, pepAc, pepAd, pepF and combinations thereof. The recombinant fungal cells may include further inactivated chromosomal genes which correspond to pepA, pepB, pepC and pepD. The recombinant filamentous fungal cells may include a heterologous nucleic acid encoding a protein of interest. Also provided are methods of producing a protein of interest in said recombinant filamentous fungal cell.
Public/Granted literature
- US20140287462A1 GENE INACTIVATED MUTANTS WITH ALTERED PROTEIN PRODUCTION Public/Granted day:2014-09-25
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