Invention Grant
US09273283B2 Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
有权
产生表达嵌合受体的T细胞受体缺陷型T细胞的方法
- Patent Title: Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
- Patent Title (中): 产生表达嵌合受体的T细胞受体缺陷型T细胞的方法
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Application No.: US13459664Application Date: 2012-04-30
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Publication No.: US09273283B2Publication Date: 2016-03-01
- Inventor: Charles L. Sentman
- Applicant: Charles L. Sentman
- Applicant Address: US NH Hanover
- Assignee: THE TRUSTEES OF DARTMOUTH COLLEGE
- Current Assignee: THE TRUSTEES OF DARTMOUTH COLLEGE
- Current Assignee Address: US NH Hanover
- Agency: LeClairRyan, A Professional Corporation
- Agent Robin L. Teskin
- Main IPC: C12N15/00
- IPC: C12N15/00 ; C12N5/0783 ; A61K39/00
Abstract:
The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In one embodiment, this invention broadly relates to TCR-deficient T cells, isolated populations thereof, and compositions comprising the same. In another embodiment of the invention, these TCR-deficient T cells are designed to express a functional non-TCR receptor. The invention also pertains to methods of making said TCR-deficient T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said TCR-deficient T cells, populations thereof, or compositions comprising the same.
Public/Granted literature
- US20120302466A1 T CELL RECEPTOR-DEFICIENT T CELL COMPOSITIONS Public/Granted day:2012-11-29
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