Invention Grant
- Patent Title: Tetracycline-regulated gene expression in HSV-1 vectors
- Patent Title (中): 四环素调节基因在HSV-1载体中的表达
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Application No.: US11117375Application Date: 2005-04-29
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Publication No.: US09273326B2Publication Date: 2016-03-01
- Inventor: Feng Yao
- Applicant: Feng Yao
- Applicant Address: US MA Boston
- Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
- Current Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
- Current Assignee Address: US MA Boston
- Agency: Nixon Peabody LLP
- Main IPC: C12N15/869
- IPC: C12N15/869 ; C12N15/86
Abstract:
The present invention is directed to HSV-1 vectors which rely on the tetracycline repressor and operator as a means for regulating expression. The vectors utilize VP-16 responsive promoters of HSV to control expression of the tetracycline repressor. The vectors are of particular interest as vehicles for recombinantly expressing genes in vivo.
Public/Granted literature
- US20050266564A1 Tetracycline-regulated gene expression in HSV-1 vectors Public/Granted day:2005-12-01
Information query
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