Systems and methods for remote actuation of a downhole tool include a work string providing a flow path therein, a downhole tool coupled to the work string, at least one actuation device operatively coupled to the downhole tool and configured to act on the downhole tool such that the downhole tool performs a predetermined action, and an optical computing device communicably coupled to the at least one actuation device and configured to detect a characteristic of a substance in the flow path and trigger actuation of the at least actuation device when the characteristic is detected.