An air intake system for a work vehicle may include a filter assembly having a pre-cleaner and an air filter. The filter assembly may define at least one outlet port. The air intake system may also include an air valve movable between an opened position and a closed position and a blower coupled to the outlet port via a conduit. The blower may be configured to create a vacuum within the conduit such that particulates are removed from the filter assembly through the outlet port. When the air valve is in the opened position, an airflow may be directed through the filter assembly in an intake direction from the pre-cleaner through the air filter and, when the air valve is in the closed position, the airflow may be directed through the air filter in a reverse direction.