A differential communication system includes a first differential communication device including a differential transmitter, a second differential communication device including a differential receiver, and a differential isolator coupling the differential transmitter to the differential receiver. The differential receiver includes a comparator operative to develop waveform region information from the received waveform, a filter adapted to remove noise from the received waveform using the waveform region information, and an adaptive sampler adapted to adjust a received waveform sampling point after it has been filtered.