The present invention relates to a system of real time micro hot cell image control for radiopharmaceutical automatic synthesizing apparatus including at least one CCD camera, a plurality of radioactivity detector, a logic control device, a computer interface control device. The plurality of radioactivity detector are connected to the logic control device, and the logic control device sends a corresponding location code to the computer interface control device when the detected radioactivity value is greater than the threshold value for selecting a nearest CCD camera and sending the taken image of the location to the computer interface control device for monitoring whether the automatic production line of radiopharmaceuticals is kept in normal operation.