Techniques for performing cell detection with interference cancellation are described. In an aspect, a user equipment (UE) may detect for pilots from cells in a wireless network using interference cancellation. The UE may process a received signal to detect for pilots from one or more cells. The pilots may be common pilots transmitted with a reuse factor of one or low reuse pilots transmitted with a reuse factor greater than one. The UE may estimate the interference from a detected cell (e.g., the strongest detected cell) and may cancel the estimated interference from the received signal. The UE may then process the interference-canceled signal to detect for pilots from additional cells. The UE may be able to detect pilots from more cells, e.g., from weaker cells, by canceling the interference due to the pilots from the detected cells. This may be desirable for various applications such as positioning.