A post-operative compression bra (1) having an opening located between two portions, a front right portion (2) and a front left portion (3) that are secured together using strap clips (9) that allow pressure being exerted by the bra on a patient to be adjusted. Rounded notches (19) are located on an upper edge (17) of a right side portion (12) and a left side portion (13) to prevent the side portions from coming into contact with a patient's lymph nodes. The side portions and a rear portion (20) may also be partially constructed out of a mesh material to allow for air flow to the skin. A drain apron (30) provides storage for drain bulbs (32).