A quick-release handle is used in positioning a retractor blade in a surgical site and securing the retractor blade to a retractor frame. The retractor blade has a generally cylindrical post for removably engaging a retractor frame, an alignment groove on its top surface, and an annular recess extending around the post. The quick-release handle has a head with a U-shaped flange for sliding engagement with the annular recess and the upper portion of the post. The handle also contains a sliding rod actuated by a thumb-slide mechanism to engage the alignment groove on the retractor blade post. In particular, a locking tongue extending from the distal end of the rod engages the alignment groove, while a protrusion extending from the rod engages the annular recess, thereby maintaining proper rotational alignment between the handle and retractor blade.