Invention Grant
US09278085B2 Side-chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
有权
用于治疗线粒体疾病和其他条件的氧化还原活性治疗剂的侧链变体和能量生物标志物的调节
- Patent Title: Side-chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
- Patent Title (中): 用于治疗线粒体疾病和其他条件的氧化还原活性治疗剂的侧链变体和能量生物标志物的调节
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Application No.: US11710042Application Date: 2007-02-22
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Publication No.: US09278085B2Publication Date: 2016-03-08
- Inventor: Guy M. Miller , Sidney M. Hecht , Orion D. Jankowski , Kieron E. Wesson , Paul Mollard
- Applicant: Guy M. Miller , Sidney M. Hecht , Orion D. Jankowski , Kieron E. Wesson , Paul Mollard
- Applicant Address: US CA Mountain View
- Assignee: Edison Pharmaceuticals, Inc.
- Current Assignee: Edison Pharmaceuticals, Inc.
- Current Assignee Address: US CA Mountain View
- Agency: Squire Patton Boggs (US) LLP
- Main IPC: A61K31/355
- IPC: A61K31/355 ; A61K31/05 ; C07C39/08 ; C07C39/11 ; C07C39/19 ; C07C39/24 ; C07C50/02 ; C07C50/06 ; C07C50/24 ; C07C50/28 ; C07C215/56 ; C07C403/04 ; C07C403/08 ; C07C403/18
Abstract:
Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), or Kearns-Sayre Syndrome (KSS) are disclosed, as well as compounds useful in the methods of the invention. Methods and compounds useful in treating other disorders are also disclosed. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed.
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