Invention Grant
- Patent Title: HMGB1 binding nucleic acid molecule and applications thereof
- Patent Title (中): HMGB1结合核酸分子及其应用
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Application No.: US13383826Application Date: 2010-07-16
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Publication No.: US09278108B2Publication Date: 2016-03-08
- Inventor: Hiromi Takenaka , Jou Akitomi , Shintarou Katou , Shotaro Tsuji , Takashi Ohtsu , Iwao Waga
- Applicant: Hiromi Takenaka , Jou Akitomi , Shintarou Katou , Shotaro Tsuji , Takashi Ohtsu , Iwao Waga
- Applicant Address: JP Tokyo JP Yokohama-shi, Kanagawa
- Assignee: NEC Solution Innovators, Ltd.,Kanagawa Prefectural Hospital Organization
- Current Assignee: NEC Solution Innovators, Ltd.,Kanagawa Prefectural Hospital Organization
- Current Assignee Address: JP Tokyo JP Yokohama-shi, Kanagawa
- Agency: McGinn IP Law Group, PLLC
- Priority: JP2009-167622 20090716
- International Application: PCT/JP2010/062104 WO 20100716
- International Announcement: WO2011/007876 WO 20110120
- Main IPC: C12N15/115
- IPC: C12N15/115 ; A61K31/7088 ; A61K31/7105 ; C07K14/47 ; G01N33/68

Abstract:
A nucleic acid molecule that can bind to HMGB1 protein and applications thereof are provided. A nucleic acid molecule having a dissociation constant for HMGB1 protein of 5×10−7 or less can be used as the nucleic acid molecule that can bind to HMGB1 protein. The HMGB1 binding nucleic acid molecule can bind to HMGB1 protein that is known to be a cause of diseases such as cancer and inflammation, and it is therefore possible to obtain an effect to prevent and an effect to treat such diseases by allowing the HMGB1 binding nucleic acid molecule to bind to HMGB1 protein in a living body.
Public/Granted literature
- US20120208867A1 HMGB1 BINDING NUCLEIC ACID MOLECULE AND APPLICATIONS THEREOF Public/Granted day:2012-08-16
Information query
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