Invention Grant
- Patent Title: Pharmaceutical compositions comprising attenuated Plasmodium sporozoites and glycolipid adjuvants
- Patent Title (中): 包含减毒的疟原虫子孢子和糖脂佐剂的药物组合物
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Application No.: US14065012Application Date: 2013-10-28
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Publication No.: US09278125B2Publication Date: 2016-03-08
- Inventor: Sumana Chakravarty , Stephen L. Hoffman , Moriya Tsuji
- Applicant: Sanaria Inc. , The Rockefeller University
- Applicant Address: US MD Rockville US NY New York
- Assignee: SANARIA INC.,THE ROCKEFELLER UNIVERSITY
- Current Assignee: SANARIA INC.,THE ROCKEFELLER UNIVERSITY
- Current Assignee Address: US MD Rockville US NY New York
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Main IPC: A61K39/015
- IPC: A61K39/015 ; A61K39/39 ; A61K9/00 ; A61K39/00
Abstract:
Disclosed herein are pharmaceutical compositions comprising Plasmodium sporozoite-stage parasites and compatible glycolipid adjuvants useful in vaccines for preventing or reducing the risk of malaria. In particular, human host range Plasmodium and analogues of α-galactosylceramide (α-GalCer), a ligand for natural killer T (NKT) cells, are combined in pharmaceutical compositions, which are useful as vaccines against malaria. Methods of use are also provided.
Public/Granted literature
- US20140120138A1 PHARMACEUTICAL COMPOSITIONS COMPRISING ATTENUATED PLASMODIUM SPOROZOITES AND GLYCOLIPID ADJUVANTS Public/Granted day:2014-05-01
Information query
