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US09278131B2 Process for lowering the viscosity of highly concentrated protein solutions 有权
降低高浓度蛋白质溶液粘度的方法

Process for lowering the viscosity of highly concentrated protein solutions
Abstract:
A process of lowering the viscosity of a solution includes preparing a solution comprising a compound of formula I, at a concentration in the final formulation of between 10 and 250 mM, and a protein having at least one antibody fragment whose concentration is between 50 and 350 mg/mL and whose pH is between 5 and 8. The compound lowers the viscosity of the solution, which is difficult to inject, by a value of at least 15% relative to the viscosity of a solution of at least one protein having at least one antibody fragment of the same concentration and of the same pH not containing the compound.
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