Invention Grant
- Patent Title: Process for lowering the viscosity of highly concentrated protein solutions
- Patent Title (中): 降低高浓度蛋白质溶液粘度的方法
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Application No.: US13962324Application Date: 2013-08-08
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Publication No.: US09278131B2Publication Date: 2016-03-08
- Inventor: Emmanuel Dauty , Thomas Ballet , Remi Soula
- Applicant: ADOCIA
- Applicant Address: FR Lyons
- Assignee: ADOCIA
- Current Assignee: ADOCIA
- Current Assignee Address: FR Lyons
- Agency: Oliff PLC
- Priority: FR1257775 20120810
- Main IPC: A61K47/18
- IPC: A61K47/18 ; A61K47/16 ; A61K39/395 ; C07K16/22 ; C07K16/24 ; C07K16/28 ; A61K9/00

Abstract:
A process of lowering the viscosity of a solution includes preparing a solution comprising a compound of formula I, at a concentration in the final formulation of between 10 and 250 mM, and a protein having at least one antibody fragment whose concentration is between 50 and 350 mg/mL and whose pH is between 5 and 8. The compound lowers the viscosity of the solution, which is difficult to inject, by a value of at least 15% relative to the viscosity of a solution of at least one protein having at least one antibody fragment of the same concentration and of the same pH not containing the compound.
Public/Granted literature
- US20140044708A1 Process for lowering the viscosity of highly concentrated protein solutions Public/Granted day:2014-02-13
Information query
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