Invention Grant
- Patent Title: Peptide linkers for effective multivalent peptide binding
- Patent Title (中): 用于有效多价肽结合的肽接头
-
Application No.: US14191871Application Date: 2014-02-27
-
Publication No.: US09278138B2Publication Date: 2016-03-08
- Inventor: Qiong Cheng , Stephen R. Fahnestock , Hongxian He , Kristy N. Kostichka , Hong Wang
- Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
- Applicant Address: US DE Wilmington
- Assignee: E. I. DU PONT DE NEMOURS AND COMPANY
- Current Assignee: E. I. DU PONT DE NEMOURS AND COMPANY
- Current Assignee Address: US DE Wilmington
- Agency: E.I. Du Pont De Nemours and Company
- Main IPC: C07K7/04
- IPC: C07K7/04 ; C07K7/08 ; A61K38/04 ; A61K38/16 ; A61Q5/00 ; A61K47/48 ; C07K14/00 ; G01N33/68 ; G06F19/16 ; A61K8/64

Abstract:
Short single chain peptides having affinity for a target surface often lack the binding durability required for certain commercial applications. One way to improve durability is to promote multivalent binding by linking together binding sequences using peptide linkers. However, the resulting single chain binding peptides often suffer from linker entropy. It has been discovered that the use of rigid peptide linkers when linking together multiple binding sequences enhances the binding affinity of the resulting single chain peptide.
Public/Granted literature
- US20140241999A1 PEPTIDE LINKERS FOR EFFECTIVE MULTIVALENT PEPTIDE BINDING Public/Granted day:2014-08-28
Information query