Invention Grant
- Patent Title: GLP-1 receptor stabilizers and modulators
- Patent Title (中): GLP-1受体稳定剂和调节剂
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Application No.: US14122176Application Date: 2012-05-31
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Publication No.: US09278910B2Publication Date: 2016-03-08
- Inventor: Marcus F. Boehm , Esther Martinborough , Manisha Moorjani , Junko Tamiya , Liming Huang , Thomas Fowler , Andrew Novak , Premji Meghani , Enugurthi Brahmachary , Adam Richard Yeager
- Applicant: Marcus F. Boehm , Esther Martinborough , Manisha Moorjani , Junko Tamiya , Liming Huang , Thomas Fowler , Andrew Novak , Premji Meghani , Enugurthi Brahmachary , Adam Richard Yeager
- Applicant Address: US CA San Diego
- Assignee: Receptos, Inc.
- Current Assignee: Receptos, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Seed IP Law Group PLLC
- International Application: PCT/US2012/040250 WO 20120531
- International Announcement: WO2012/166951 WO 20121206
- Main IPC: C07D271/06
- IPC: C07D271/06 ; C07C235/38 ; A61K9/00 ; A61K47/20 ; A61K47/26 ; A61K47/40 ; A61K47/48 ; A61K45/06 ; A61K31/155 ; A61K38/26 ; C07C255/57 ; C07D213/79 ; C07D213/80 ; C07D213/81 ; C07D213/82 ; C07D309/06 ; C07D309/08 ; C07D311/16 ; C07C271/28 ; C07D215/48 ; C07D217/02 ; C07C275/42 ; C07D317/68 ; C07D231/12 ; C07D333/38 ; C07D233/60 ; C07C311/08 ; C07C311/13 ; C07C311/21 ; C07D235/06 ; C07C311/29 ; C07D235/12 ; C07D235/18 ; C07C311/48 ; C07D239/26 ; C07D239/28 ; C07C317/28 ; C07C317/44 ; C07D239/74 ; C07D413/04 ; C07D239/91 ; C07D413/12 ; C07D241/42 ; C07D241/44 ; C07D417/12 ; C07C323/62 ; C07C229/14 ; C07D249/08 ; C07D257/04 ; C07C233/47 ; C07C233/51 ; C07D261/18 ; C07C233/81 ; C07C233/83 ; C07C235/12 ; C07D263/32 ; C07D263/34 ; C07C235/48 ; C07D263/48 ; C07D263/57 ; C07C237/22 ; C07C237/36 ; C07C237/42 ; C07D271/07 ; C07D271/107 ; C07D207/267 ; C07D277/30 ; C07D209/08 ; C07D277/56 ; C07D277/66 ; C07D279/12 ; C07D211/14 ; C07D211/34 ; C07D211/62 ; C07D295/15 ; C07D295/155 ; C07D295/205 ; C07D213/55 ; C07D213/65 ; C07D307/24 ; C07D307/54 ; C07D307/68 ; C07D307/79 ; C08B37/16 ; C08L5/16 ; B82Y5/00 ; A61K31/235 ; A61K31/341 ; A61K31/4406 ; A61K31/4465 ; A61K31/495 ; A61K31/505 ; A61K31/5375 ; A61K31/54 ; C07D295/24
Abstract:
Compounds that bind the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, methods of their therapeutic and/or prophylactic use, and methods of their use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor are provided. Certain compounds may have activity as modulators or potentiators with respect to glucagon receptor, GIP receptor, GLP-1 and GLP-2 receptors, and PTH receptor on their own or in the presence of receptor ligands such as GIP(1-42), PTH(1-34), Glucagon(1-29), GLP-2(1-33), GLP-1 (7-36), GLP-1 (9-36), oxyntomodulin and exendin variants.
Public/Granted literature
- US20140336185A1 NOVEL GLP-1 RECEPTOR STABILIZERS AND MODULATORS Public/Granted day:2014-11-13
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