Invention Grant
- Patent Title: Methods for increasing the stabilization of hypoxia inducible factor-α
- Patent Title (中): 增加缺氧诱导因子α稳定性的方法
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Application No.: US14628261Application Date: 2015-02-22
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Publication No.: US09278930B2Publication Date: 2016-03-08
- Inventor: Robert Shalwitz , Joseph H. Gardner
- Applicant: Aerpio Therapeutics Inc.
- Applicant Address: US OH Cincinnati
- Assignee: AERPIO THERAPEUTICS, INC.
- Current Assignee: AERPIO THERAPEUTICS, INC.
- Current Assignee Address: US OH Cincinnati
- Agency: Wilson Sonsini Goodrich & Rosati
- Main IPC: A61K31/4412
- IPC: A61K31/4412 ; C07D211/96 ; A61K31/44 ; A61K31/4439 ; A61K31/4545 ; A61K31/496 ; A61K31/501 ; A61K31/5377 ; A61K31/541 ; A61K31/55 ; C07D213/02 ; C07D213/69 ; C07D401/06 ; C07D401/14 ; C07D417/06 ; C07D491/113 ; A61K31/4427 ; A61K31/444 ; A61K45/06 ; C07D211/86
Abstract:
Disclosed herein are methods for controlling the activity of hypoxia-inducible transcription factor 1-alpha (HIF-1α) and diseases, conditions, or syndromes related thereto, inter alia, Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, and anemia. Further disclosed are pharmaceutical compositions comprising HIF-1α prolyl hydroxylase inhibitors useful in treating diseases, conditions, and/or syndromes related thereto the activity of HIF-1α.
Public/Granted literature
- US20150157617A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA Public/Granted day:2015-06-11
Information query
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