Invention Grant
- Patent Title: Method for producing fine particles of aripiprazole anhydride crystals B
- Patent Title (中): 制备阿立哌唑酐晶体微粒的方法B
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Application No.: US14128305Application Date: 2012-06-29
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Publication No.: US09278934B2Publication Date: 2016-03-08
- Inventor: Takuji Bando , Katsuhiko Yano , Makoto Fukana , Satoshi Aoki
- Applicant: Takuji Bando , Katsuhiko Yano , Makoto Fukana , Satoshi Aoki
- Applicant Address: JP Tokyo
- Assignee: OTSUKA PHARMACEUTICAL CO., LTD.
- Current Assignee: OTSUKA PHARMACEUTICAL CO., LTD.
- Current Assignee Address: JP Tokyo
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- International Application: PCT/JP2012/067258 WO 20120629
- International Announcement: WO2013/002420 WO 20130103
- Main IPC: C07D401/12
- IPC: C07D401/12 ; C07D403/02 ; C07D215/22

Abstract:
The present invention provides a novel method for producing fine particles of aripiprazole anhydride crystals B. The method for producing fine particles of aripiprazole anhydride crystals B comprises the steps of: (1) heating and dissolving crude aripiprazole in a lower alcohol, and subsequently cooling the resulting mixture to precipitate crystals to obtain crystals of aripiprazole lower alcohol solvate; (2) subjecting the crystals of aripiprazole lower alcohol solvate to wet-milling in the form of a slurry containing the lower alcohol; and (3) subjecting the dispersion of the wet-milled crystals to solid-liquid separation to obtain the crystals, and heating the crystals.
Public/Granted literature
- US20140228567A1 Method for Producing Fine Particles of Aripiprazole Anhydride Crystals B Public/Granted day:2014-08-14
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