Invention Grant
US09278936B2 Crystalline forms of 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)benzyl)urea hydrochloride
有权
1-（3-叔丁基-1-对甲苯基-1H-吡唑-5-基）-3-（5-氟-2-（1-（2-羟基乙基）-1H-吲唑-5-基） 氧基）苄基）脲盐酸盐
- Patent Title: Crystalline forms of 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)benzyl)urea hydrochloride
- Patent Title (中): 1-（3-叔丁基-1-对甲苯基-1H-吡唑-5-基）-3-（5-氟-2-（1-（2-羟基乙基）-1H-吲唑-5-基） 氧基）苄基）脲盐酸盐
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Application No.: US14382178Application Date: 2013-02-27
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Publication No.: US09278936B2Publication Date: 2016-03-08
- Inventor: Alisha B. Arrigo , Donald T. Corson , Coralee G. Mannila
- Applicant: Array BioPharma Inc.
- Applicant Address: US CO Boulder
- Assignee: ARRAY BIOPHARMA INC.
- Current Assignee: ARRAY BIOPHARMA INC.
- Current Assignee Address: US CO Boulder
- Agency: Viksnins Harris & Padys PLLP
- Agent Sarah S. Mastous
- International Application: PCT/US2013/027979 WO 20130227
- International Announcement: WO2013/130573 WO 20130906
- Main IPC: C07D231/56
- IPC: C07D231/56 ; A61K31/4155
Abstract:
Provided herein is a hydrogen chloride salt of 1-(3-/t?r/-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)benzyl)urea, crystalline forms of 1-(3-½^butyl-1^-tolyl-1H-pyrazol-5-yl)-3-(5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)benzyl)urea hydrochloride, processes for the preparation of said crystalline forms, pharmaceutical compositions containing a crystalline form of 1-(3-r
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