Invention Grant
US09278963B2 Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors
有权
嘧啶羟基酰胺化合物作为组蛋白脱乙酰酶抑制剂
- Patent Title: Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors
- Patent Title (中): 嘧啶羟基酰胺化合物作为组蛋白脱乙酰酶抑制剂
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Application No.: US14510711Application Date: 2014-10-09
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Publication No.: US09278963B2Publication Date: 2016-03-08
- Inventor: John H. van Duzer , Ralph Mazitschek , Simon Stewart Jones , Min Yang , David Lee Tamang
- Applicant: Acetylon Pharmaceuticals, Inc.
- Applicant Address: US MA Boston
- Assignee: Acetylon Pharmaceuticals, Inc.
- Current Assignee: Acetylon Pharmaceuticals, Inc.
- Current Assignee Address: US MA Boston
- Agency: Lathrop & Gage LLP
- Agent Brian C. Trinque
- Main IPC: A61K31/506
- IPC: A61K31/506 ; C07D417/12 ; C07D401/12 ; C07D401/14 ; C07D239/42

Abstract:
Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with HDAC activity, particularly diseases or disorders that involve activity of HDAC1, HDAC2, and/or HDAC6. Also provided herein are methods for inhibiting migration of a neuroblastoma cell, inducing maturation of a neuroblastoma cell, and altering cell cycle progression of a neuroblastoma cell comprising administering to the cell a therapeutically effective amount of a HDAC1, HDAC2, and/or HDAC6 selective inhibitor or a pharmaceutically acceptable salt thereof.
Public/Granted literature
- US20150105384A1 PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS Public/Granted day:2015-04-16
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