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US09278963B2 Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors 有权
嘧啶羟基酰胺化合物作为组蛋白脱乙酰酶抑制剂

Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors
Abstract:
Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with HDAC activity, particularly diseases or disorders that involve activity of HDAC1, HDAC2, and/or HDAC6. Also provided herein are methods for inhibiting migration of a neuroblastoma cell, inducing maturation of a neuroblastoma cell, and altering cell cycle progression of a neuroblastoma cell comprising administering to the cell a therapeutically effective amount of a HDAC1, HDAC2, and/or HDAC6 selective inhibitor or a pharmaceutically acceptable salt thereof.
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