Invention Grant
- Patent Title: Imidazopyridine compounds
- Patent Title (中): 咪唑并吡啶化合物
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Application No.: US14428798Application Date: 2013-11-28
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Publication No.: US09278968B2Publication Date: 2016-03-08
- Inventor: Toshio Kurosaki , Tsubasa Watanabe , Kazuhiko Ohne , Hiroki Ishioka , Eisuke Nozawa , Takeshi Hanazawa , Shunichiro Hachiya , Hiroshi Shibata , Yuji Koga , Ryo Mizoguchi
- Applicant: ASTELLAS PHARMA INC.
- Applicant Address: JP Tokyo
- Assignee: Astellas Pharma Inc.
- Current Assignee: Astellas Pharma Inc.
- Current Assignee Address: JP Tokyo
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2012-262962 20121130
- International Application: PCT/JP2013/082057 WO 20131128
- International Announcement: WO2014/084312 WO 20140605
- Main IPC: A61K31/437
- IPC: A61K31/437 ; C07D471/04

Abstract:
[Problem]A pharmaceutical composition for treating or preventing various cardiovascular diseases, which have sGC activities based on improvement of cGMP signals, is provided.[Means for Solution]It was found that imidazo[1,2-a]pyridine compounds having a carbamoyl group at the 3-position and a particular cyclic group at the 8-position via a methyleneoxy group, or a salt thereof have sGC activation, and are useful as active ingredients of pharmaceutical compositions for treating or preventing various sGC-related cardiovascular diseases, in particular, peripheral arterial diseases, intermittent claudication, critical limb ischemia, hypertension, and pulmonary hypertension, thereby completing the present invention.
Public/Granted literature
- US20150232464A1 IMIDAZOPYRIDINE COMPOUNDS Public/Granted day:2015-08-20
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