Invention Grant
- Patent Title: Organic compounds
- Patent Title (中): 有机化合物
-
Application No.: US14459567Application Date: 2014-08-14
-
Publication No.: US09278969B2Publication Date: 2016-03-08
- Inventor: Gary Michael Ksander , Erik Meredith , Lauren Monovich , Julien Papillon , Fariborz Firooznia , Qi-Ying Hu
- Applicant: Gary Michael Ksander , Erik Meredith , Lauren Monovich , Julien Papillon , Fariborz Firooznia , Qi-Ying Hu
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Michelle Han
- Main IPC: C07D401/02
- IPC: C07D401/02 ; C07D401/10 ; A61K31/437 ; A61K31/4353 ; C07D471/04 ; C07D487/04 ; A61K31/4188 ; A61K31/454 ; A61K31/5377 ; A61K45/06 ; A61K31/55

Abstract:
The present invention provides a compound of formula I: Said compound is inhibitor of aldosterone synthase and aromatase, and thus can be employed for the treatment of a disorder or disease mediated by aldosterone synthase or aromatase. Accordingly, the compound of formula I can be used in treatment of hypokalemia, hypertension, congestive heart failure, atrial fibrillation, renal failure, in particular, chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity, nephropathy, post-myocardial infarction, coronary heart diseases, inflammation, increased formation of collagen, fibrosis such as cardiac or myocardiac fibrosis and remodeling following hypertension and endothelial dysfunction, gynecomastia, osteoporosis, prostate cancer, endometriosis, uterine fibroids, dysfunctional uterine bleeding, endometrial hyperplasia, polycystic ovarian disease, infertility, fibrocystic breast disease, breast cancer and fibrocystic mastopathy. Finally, the present invention also provides a pharmaceutical composition.
Public/Granted literature
- US20140357621A1 Organic Compounds Public/Granted day:2014-12-04
Information query