Invention Grant
US09278979B2 Synthetic process for preparation of macrocyclic C1-keto analogs of halichondrin B and intermediates useful therein
有权
用于制备软碱蛋白B的大环C1-酮类似物的合成方法及其中有用的中间体
- Patent Title: Synthetic process for preparation of macrocyclic C1-keto analogs of halichondrin B and intermediates useful therein
- Patent Title (中): 用于制备软碱蛋白B的大环C1-酮类似物的合成方法及其中有用的中间体
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Application No.: US14389439Application Date: 2013-03-28
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Publication No.: US09278979B2Publication Date: 2016-03-08
- Inventor: Fabio E. S. Souza , Alena Rudolph , Ming Pan , Boris Gorin , Teng Ko Ngooi , Jason A. Bexrud , Ricardo Orprecio , Huzaifa Rangwala
- Applicant: ALPHORA RESEARCH INC.
- Applicant Address: CA Mississauga
- Assignee: ALPHORA RESEARCH INC.
- Current Assignee: ALPHORA RESEARCH INC.
- Current Assignee Address: CA Mississauga
- Agency: Grossman, Tucker, Perreault & Pfleger, PLLC
- International Application: PCT/CA2013/050254 WO 20130328
- International Announcement: WO2013/142999 WO 20131003
- Main IPC: C07D493/22
- IPC: C07D493/22 ; C07D407/14 ; C07D493/04 ; C07D307/20 ; C07C309/04
Abstract:
Disclosed is a compound of formula 1, or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, R7, R7′, R8, R9, R10, R11, R12 and R13 are as disclosed herein. Also, disclosed is a process for the preparation of the compound of formula 1, or a pharmaceutically acceptable salt thereof, and intermediates used therein. The compound of formula 1 can be used in the preparation of halichondrin analogs, such as Eribulin; and a process for its preparation from the compound of formula 1 is also disclosed.
Public/Granted literature
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