Invention Grant
US09278981B2 Compounds and compositions for inhibiting the activity of ABL1, ABL2 and BCR-ABL1
有权
用于抑制ABL1，ABL2和BCR-ABL1活性的化合物和组合物
- Patent Title: Compounds and compositions for inhibiting the activity of ABL1, ABL2 and BCR-ABL1
- Patent Title (中): 用于抑制ABL1，ABL2和BCR-ABL1活性的化合物和组合物
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Application No.: US14400987Application Date: 2013-05-09
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Publication No.: US09278981B2Publication Date: 2016-03-08
- Inventor: Pascal Furet , Robert Martin Grotzfeld , Wolfgang Jahnke , Darryl Brynley Jones , Paul William Manley , Andreas Marzinzik , Xavier Francois Andre Pelle , Bahaa Salem , Joseph Schoepfer , Erich Alois Spieser
- Applicant: Pascal Furet , Robert Martin Grotzfeld , Wolfgang Jahnke , Darryl Brynley Jones , Paul William Manley , Andreas Marzinzik , Xavier Francois Andre Pelle , Bahaa Salem , Joseph Schoepfer , Erich Alois Spieser
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Scott W. Reid
- International Application: PCT/IB2013/053769 WO 20130509
- International Announcement: WO2013/171640 WO 20131121
- Main IPC: A61K31/4439
- IPC: A61K31/4439 ; C07D498/08 ; C07D401/14 ; C07D405/14 ; C07D413/14 ; C07D401/04 ; C07D401/10 ; C07D403/10 ; C07D413/10 ; C07D471/04 ; C07D487/04 ; C07D487/10 ; C07D491/10 ; A61K31/444 ; A61K31/4545 ; A61K31/4725 ; A61K31/498 ; A61K31/5025 ; A61K31/506 ; A61K31/551 ; A61K31/553 ; A61K45/06 ; C07D491/107
Abstract:
The present invention relates to compounds of formula (I): in which Y, Y, R, R 2, R 3 and R 4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.
Public/Granted literature
- US20150183801A1 COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1 Public/Granted day:2015-07-02
Information query
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