Invention Grant
US09278982B2 Targeting human thymidylate kinase induces DNA repair toxicity in malignant tumor cells
有权
靶向人胸苷酸激酶诱导恶性肿瘤细胞中的DNA修复毒性
- Patent Title: Targeting human thymidylate kinase induces DNA repair toxicity in malignant tumor cells
- Patent Title (中): 靶向人胸苷酸激酶诱导恶性肿瘤细胞中的DNA修复毒性
-
Application No.: US13990398Application Date: 2011-11-29
-
Publication No.: US09278982B2Publication Date: 2016-03-08
- Inventor: Zee Fen Chang , Jim-Min Fang , Chun-Mei Hu , Ming-Tyng Yeh
- Applicant: Zee Fen Chang , Jim-Min Fang , Chun-Mei Hu , Ming-Tyng Yeh
- Applicant Address: TW Taipei TW Taipei
- Assignee: NATIONAL YANG-MING UNIVERSITY,NATIONAL TAIWAN UNIVERSITY
- Current Assignee: NATIONAL YANG-MING UNIVERSITY,NATIONAL TAIWAN UNIVERSITY
- Current Assignee Address: TW Taipei TW Taipei
- Agency: Muncy, Geissler, Olds & Lowe, P.C.
- International Application: PCT/CN2011/083103 WO 20111129
- International Announcement: WO2012/072019 WO 20120607
- Main IPC: C07D513/04
- IPC: C07D513/04 ; C07D275/04 ; C07D275/06 ; A61K31/403 ; A61K31/425 ; A61K31/704 ; A61K45/06
Abstract:
The present invention relates to novel TMPK inhibitor compositions and their methods of use. In particular, it relates to novel TMPK inhibitor compositions and therapeutics that lead to dUTP-mediated DNA repair in tumor cells and acts as a novel chemosensitizer, which are useful in methods for treating or preventing cancers.
Public/Granted literature
- US20130252953A1 Targeting Human Thymidylate Kinase Induces DNA Repair Toxicity in Malignant Tumor Cells Public/Granted day:2013-09-26
Information query
