Invention Grant
US09278991B2 Anhydrous polymorphs of [(2R,3S,4R,5R)-5-(6-(cyclopentylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)} methyl nitrate and processes of preparation thereof
有权
[（2R，3S，4R，5R）-5-（6-（环戊基氨基）-9H-嘌呤-9-基）-3,4-二羟基四氢呋喃-2-基）}甲基硝酸酯的无水多晶型物及其制备方法
- Patent Title: Anhydrous polymorphs of [(2R,3S,4R,5R)-5-(6-(cyclopentylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)} methyl nitrate and processes of preparation thereof
- Patent Title (中): [（2R，3S，4R，5R）-5-（6-（环戊基氨基）-9H-嘌呤-9-基）-3,4-二羟基四氢呋喃-2-基）}甲基硝酸酯的无水多晶型物及其制备方法
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Application No.: US13750389Application Date: 2013-01-25
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Publication No.: US09278991B2Publication Date: 2016-03-08
- Inventor: William K. McVicar
- Applicant: Inotek Pharmaceuticals Corporation
- Applicant Address: US MA Lexington
- Assignee: Inotek Pharmaceuticals Corporation
- Current Assignee: Inotek Pharmaceuticals Corporation
- Current Assignee Address: US MA Lexington
- Agency: Nelson Mullins Riley & Scarborough LLP
- Agent Jane E. Remillard, Esq.; Cynthia L. Kanik
- Main IPC: A01N43/04
- IPC: A01N43/04 ; A61K31/70 ; C07H19/167 ; C07H19/173 ; C07H19/16 ; C07H1/06
Abstract:
The present invention provides novel anhydrous polymorph forms of 2R,3S,4R,5R)-5-(6-(cyclopentylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl) methyl nitrate (Compound A), a selective adenosine A1 receptor agonist with a number of therapeutic uses including the treatment of elevated intra-ocular pressure. Also provided are methods for the preparation of the anhydrous polymorphic forms of compound A, pharmaceutical compositions and methods of treatment.
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