Invention Grant
US09279000B2 High-cell density fed-batch fermentation process for producing recombinant protein
有权
用于生产重组蛋白的高细胞密度补料分批发酵方法
- Patent Title: High-cell density fed-batch fermentation process for producing recombinant protein
- Patent Title (中): 用于生产重组蛋白的高细胞密度补料分批发酵方法
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Application No.: US14135434Application Date: 2013-12-19
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Publication No.: US09279000B2Publication Date: 2016-03-08
- Inventor: Wei-Qiang Willie Sun , Earl Joseph Pursell
- Applicant: Wyeth LLC
- Applicant Address: US NY New York
- Assignee: Wyeth LLC
- Current Assignee: Wyeth LLC
- Current Assignee Address: US NY New York
- Agent Anna C. Chau
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K14/22 ; C12P21/02

Abstract:
Methods for producing proteins, for example, recombinant meningococcal 2086 proteins, using fed-batch fermentation with continuous input of an inducer after achieving a threshold parameter, and optionally continuous input of a carbon source, for example, a constant rate input, to improve protein yields, as well as high density protein compositions and compositions for use in the methods of the present invention, are provided.
Public/Granted literature
- US20140113329A1 HIGH-CELL DENSITY FED-BATCH FERMENTATION PROCESS FOR PRODUCING RECOMBINANT PROTEIN Public/Granted day:2014-04-24
Information query
IPC分类: