Invention Grant
US09279000B2 High-cell density fed-batch fermentation process for producing recombinant protein 有权
用于生产重组蛋白的高细胞密度补料分批发酵方法

  • Patent Title: High-cell density fed-batch fermentation process for producing recombinant protein
  • Patent Title (中): 用于生产重组蛋白的高细胞密度补料分批发酵方法
  • Application No.: US14135434
    Application Date: 2013-12-19
  • Publication No.: US09279000B2
    Publication Date: 2016-03-08
  • Inventor: Wei-Qiang Willie SunEarl Joseph Pursell
  • Applicant: Wyeth LLC
  • Applicant Address: US NY New York
  • Assignee: Wyeth LLC
  • Current Assignee: Wyeth LLC
  • Current Assignee Address: US NY New York
  • Agent Anna C. Chau
  • Main IPC: A61K38/00
  • IPC: A61K38/00 C07K14/22 C12P21/02
High-cell density fed-batch fermentation process for producing recombinant protein
Abstract:
Methods for producing proteins, for example, recombinant meningococcal 2086 proteins, using fed-batch fermentation with continuous input of an inducer after achieving a threshold parameter, and optionally continuous input of a carbon source, for example, a constant rate input, to improve protein yields, as well as high density protein compositions and compositions for use in the methods of the present invention, are provided.
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