Invention Grant
- Patent Title: FGF-21 mutants comprising polyethylene glycol and uses thereof
- Patent Title (中): 包含聚乙二醇的FGF-21突变体及其用途
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Application No.: US13123205Application Date: 2009-10-08
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Publication No.: US09279013B2Publication Date: 2016-03-08
- Inventor: Kenneth W. Walker , Colin V. Gegg, Jr. , Randy I. Hecht , Edward J. Belouski , Yue-Sheng Li , Mark L. Michaels , Jing Xu , Murielle M. Ellison
- Applicant: Kenneth W. Walker , Colin V. Gegg, Jr. , Randy I. Hecht , Edward J. Belouski , Yue-Sheng Li , Mark L. Michaels , Jing Xu , Murielle M. Ellison
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- International Application: PCT/US2009/060045 WO 20091008
- International Announcement: WO2010/042747 WO 20100415
- Main IPC: A61K38/18
- IPC: A61K38/18 ; C07K14/50 ; A61K38/00
Abstract:
The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides comprising extended in vivos half-lives, pharmaceutical compositions comprising FGF21 mutant polypeptides having extended in vivos half lives, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.
Public/Granted literature
- US20110195895A1 FGF21 MUTANTS AND USES THEREOF Public/Granted day:2011-08-11
Information query
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