Invention Grant
- Patent Title: Methods for identifying antibodies with reduced immunogenicity
- Patent Title (中): 用于鉴定具有降低的免疫原性的抗体的方法
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Application No.: US14030977Application Date: 2013-09-18
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Publication No.: US09279016B2Publication Date: 2016-03-08
- Inventor: Fiona A. Harding , Olivia Jennifer Razo
- Applicant: AbbVie Biotherapeutics Inc.
- Applicant Address: US CA Redwood City
- Assignee: AbbVie Biotherapeutics Inc.
- Current Assignee: AbbVie Biotherapeutics Inc.
- Current Assignee Address: US CA Redwood City
- Agency: Dechert LLP
- Main IPC: C40B40/10
- IPC: C40B40/10 ; C07K16/24 ; G01N33/68 ; C07K16/42 ; A61K39/00
Abstract:
The disclosure describes methods of identifying a variant of a reference antibody with reduced immunogenicity as compared to the reference antibody. The disclosure further describes variants of a reference anti-TNF-α antibody having reduced immunogenicity as compared to the reference anti-TNF-α reference antibody.
Public/Granted literature
- US20140227251A1 METHODS FOR IDENTIFYING ANTIBODIES WITH REDUCED IMMUNOGENICITY Public/Granted day:2014-08-14
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