Invention Grant
- Patent Title: Leech hyaluronidase and its application
- Patent Title (中): 水蛭透明质酸酶及其应用
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Application No.: US14251579Application Date: 2014-04-12
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Publication No.: US09279111B2Publication Date: 2016-03-08
- Inventor: Jian Chen , Guocheng Du , Zhen Kang , Peng Jin
- Applicant: Jian Chen , Guocheng Du , Zhen Kang , Peng Jin
- Applicant Address: CN Wuxi, JS
- Assignee: Jiangnan University
- Current Assignee: Jiangnan University
- Current Assignee Address: CN Wuxi, JS
- Agent Lili Chen
- Priority: CN201310323064 20130729; CN201310358573 20130815; CN201310498577 20131022; CN201310597818 20131122; CN201410007408 20140108
- Main IPC: C12N9/24
- IPC: C12N9/24 ; C12P19/26 ; C12P21/02

Abstract:
The present invention provides a novel leech HAase and a method of producing low-molecular-weight HA oligosaccharides using the leech HAase. This invention successfully cloned the first leech HAase gene and provides a method for high-level expression of the leech HAase gene. By controlling the incubation condition, different HA oligosaccharides, particularly HA4, HA6, HA8 and HA10, can be selectively generated using the leech HAase. The large-scale expression of the leech HAase and the enzymatic production of specific HA oligosaccharides are not only useful for the cosmetic, healthcare and the medical industries but also can be a great help to polysaccharides chemical synthesis and cancer research.
Public/Granted literature
- US20150031085A1 Novel Leech Hyaluronidase and Its Application Public/Granted day:2015-01-29
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