Invention Grant
- Patent Title: Dimeric bacteriophage lysins
- Patent Title (中): 二聚体噬菌体溶素
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Application No.: US14349736Application Date: 2012-10-04
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Publication No.: US09279118B2Publication Date: 2016-03-08
- Inventor: Vincent A. Fischetti , Gregory Resch
- Applicant: Vincent A. Fischetti , Gregory Resch
- Applicant Address: US NY New York
- Assignee: The Rockefeller University
- Current Assignee: The Rockefeller University
- Current Assignee Address: US NY New York
- Agency: Klauber & Jackson LLC
- International Application: PCT/US2012/058717 WO 20121004
- International Announcement: WO2013/052643 WO 20130411
- Main IPC: A61K38/46
- IPC: A61K38/46 ; C12N9/80 ; C07H21/04 ; C07K1/00 ; C07K14/005 ; A01N63/00
Abstract:
The present invention provides isolated dimeric Streptococcus-specific phage lysins having two Streptococcus-specific phage lysin monomers covalently linked to each other, and having killing activity against one or more Streptococcus bacteria. Also provided for are pharmaceutical compositions of dimeric lysins and their use in therapeutic treatment or alleviation of infections or bacterial colonizations. The dimeric lysins may also be used to decontaminate porous and non-porous surfaces or devices.
Public/Granted literature
- US20140248256A1 DIMERIC BACTERIOPHAGE LYSINS Public/Granted day:2014-09-04
Information query
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