Invention Grant
US09279119B2 Engineered enzymes with methionine-gamma-lyase enzymes and pharmacological preparations thereof
有权
具有甲硫氨酸-γ-裂解酶的工程酶及其药理学制剂
- Patent Title: Engineered enzymes with methionine-gamma-lyase enzymes and pharmacological preparations thereof
- Patent Title (中): 具有甲硫氨酸-γ-裂解酶的工程酶及其药理学制剂
-
Application No.: US14225518Application Date: 2014-03-26
-
Publication No.: US09279119B2Publication Date: 2016-03-08
- Inventor: George Georgiou , Everett Stone
- Applicant: AEMASE, INC.
- Applicant Address: US TX Austin
- Assignee: AEMase, Inc.
- Current Assignee: AEMase, Inc.
- Current Assignee Address: US TX Austin
- Agency: Parker Highlander PLLC
- Main IPC: C12N15/60
- IPC: C12N15/60 ; C12N9/88 ; C12N9/96 ; A61K38/00
Abstract:
Methods and composition related to the engineering of a novel protein with methionine-γ-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-γ-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids.
Public/Granted literature
- US20140287484A1 ENGINEERED ENZYMES WITH METHIONINE-GAMMA-LYASE ENZYMES AND PHARMACOLOGICAL PREPARATIONS THEREOF Public/Granted day:2014-09-25
Information query
IPC分类:
