Invention Grant
- Patent Title: T cell receptor display
-
Application No.: US14248919Application Date: 2014-04-09
-
Publication No.: US09279122B2Publication Date: 2016-03-08
- Inventor: Bent Karsten Jakobsen , Peter Eamon Molloy , Yi Li
- Applicant: ADAPTIMMUNE LIMITED , IMMUNOCORE LIMITED
- Applicant Address: GB Oxford GB Oxford
- Assignee: ADAPTIMMUNE LIMITED,IMMUNOCORE LIMITED
- Current Assignee: ADAPTIMMUNE LIMITED,IMMUNOCORE LIMITED
- Current Assignee Address: GB Oxford GB Oxford
- Agency: Vedder Price P.C.
- Agent Thomas J. Kowalski; Deborah L. Lu
- Priority: GB0226227.7 20021109; GB0301814.0 20030125; GB0304067.2 20030222; GB0311397.4 20030516; GB0316356.5 20030711
- Main IPC: C40B40/10
- IPC: C40B40/10 ; C12N15/10 ; C07K14/725 ; C12N7/00 ; C40B40/02 ; A61K38/00

Abstract:
A proteinaceous particle, for example a bacteriophage, ribosome or cell, displaying on its surface a T-cell receptor (TCR). The displayed TCR is preferably a heterodimer having a non-native disulfide bond between constant domain residues. Such display particles may be used for the creation of diverse TCR libraries for the identification of high affinity TCRs. Several high affinities are disclosed.
Public/Granted literature
- US20140371085A1 T CELL RECEPTOR DISPLAY Public/Granted day:2014-12-18
Information query