Invention Grant
US09279123B2 Method for promoting angiogenesis, vascularization or vessel repair or for inhibiting tumor angiogenesis 有权
促进血管生成,血管化或血管修复或抑制肿瘤血管发生的方法

Method for promoting angiogenesis, vascularization or vessel repair or for inhibiting tumor angiogenesis
Abstract:
The invention relates to a method for influencing the miR-92 expression in a cell, comprising the following steps: (a) providing a cell; and (b1) reducing the miR-92 expression in the cell in order to promote the vascularization or vessel repair by introducing an antisense molecule against miR-92 into the cell, or (b2) increasing the miR-92 expression in the cell for an inhibition of the tumor angiogenesis by introducing a construct into the cell, wherein said construct includes an expressible miR-92 sequence. Furthermore, the invention relates to a pharmaceutical composition, comprising an agent for reducing the miR-92 activity or expression in a cell in the form of an antisense molecule against miR-92, or an agent for increasing the miR-92 expression in a cell in the form of a construct for expressing miR-92.
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