Invention Grant
US09279127B2 Adipocyte-specific constructs and methods for inhibiting platelet-type 12 lipoxygenase expression
有权
脂肪细胞特异性构建体和抑制血小板12型脂氧合酶表达的方法
- Patent Title: Adipocyte-specific constructs and methods for inhibiting platelet-type 12 lipoxygenase expression
- Patent Title (中): 脂肪细胞特异性构建体和抑制血小板12型脂氧合酶表达的方法
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Application No.: US12513006Application Date: 2007-11-01
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Publication No.: US09279127B2Publication Date: 2016-03-08
- Inventor: Gary Weisinger , Rona Limor , Naftali Stern
- Applicant: Gary Weisinger , Rona Limor , Naftali Stern
- Applicant Address: IL Tel-Aviv
- Assignee: The Medical Research Fund at the Tel-Aviv Sourasky Medical Center
- Current Assignee: The Medical Research Fund at the Tel-Aviv Sourasky Medical Center
- Current Assignee Address: IL Tel-Aviv
- Agency: Winston & Strawn LLP
- International Application: PCT/IL2007/001333 WO 20071101
- International Announcement: WO2008/053487 WO 20080508
- Main IPC: C07H21/04
- IPC: C07H21/04 ; A61K31/70 ; C12N15/63 ; C12N15/113 ; A61K48/00

Abstract:
The present invention is directed to constructs, compositions and methods for modulating platelet-type 12 lipoxygenase (12-LO) in adipose tissue in vivo. Specifically, the invention provides constructs encoding expression-inhibiting oligonucleic acids, e.g., antisense and RNA interfering (RNAi) molecules, targeted to a platelet-type 12-LO gene or a transcript thereof, which are capable of reducing or silencing platelet-type 12-LO expression specifically in adipocytes and pre-adipocytes. Vectors of these constructs (including, but not limited to, viral vectors), compositions of them and methods of using same for the treatment and amelioration of conditions associated with excess fat cell mass and obesity are also provided.
Public/Granted literature
- US20110038923A1 ADIPOCYTE-SPECIFIC CONSTRUCTS AND METHODS FOR INHIBITING PLATELET-TYPE 12 LIPOXYGENASE EXPRESSION Public/Granted day:2011-02-17
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