Invention Grant
US09279127B2 Adipocyte-specific constructs and methods for inhibiting platelet-type 12 lipoxygenase expression 有权
脂肪细胞特异性构建体和抑制血小板12型脂氧合酶表达的方法

Adipocyte-specific constructs and methods for inhibiting platelet-type 12 lipoxygenase expression
Abstract:
The present invention is directed to constructs, compositions and methods for modulating platelet-type 12 lipoxygenase (12-LO) in adipose tissue in vivo. Specifically, the invention provides constructs encoding expression-inhibiting oligonucleic acids, e.g., antisense and RNA interfering (RNAi) molecules, targeted to a platelet-type 12-LO gene or a transcript thereof, which are capable of reducing or silencing platelet-type 12-LO expression specifically in adipocytes and pre-adipocytes. Vectors of these constructs (including, but not limited to, viral vectors), compositions of them and methods of using same for the treatment and amelioration of conditions associated with excess fat cell mass and obesity are also provided.
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