Invention Grant
US09279137B2 Mutant acetolactate synthase and a method for producing branched-chain L-amino acids
有权
突变乙酰乳酸合成酶和支链L-氨基酸的生产方法
- Patent Title: Mutant acetolactate synthase and a method for producing branched-chain L-amino acids
- Patent Title (中): 突变乙酰乳酸合成酶和支链L-氨基酸的生产方法
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Application No.: US14333727Application Date: 2014-07-17
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Publication No.: US09279137B2Publication Date: 2016-03-08
- Inventor: Elena Viktorovna Sycheva , Vsevolod Aleksandrovich Serebryanyy , Tatyana Abramovna Yampolskaya , Ekaterina Sergeevna Preobrazhenskaya , Natalia Viktorovna Stoynova
- Applicant: AJINOMOTO CO., INC.
- Applicant Address: JP Tokyo
- Assignee: AJINOMOTO CO., INC.
- Current Assignee: AJINOMOTO CO., INC.
- Current Assignee Address: JP Tokyo
- Agency: Cermak Nakajima & McGowan LLP
- Agent Shelly Guest Cermak
- Priority: RU2006132818 20060913
- Main IPC: C12N1/20
- IPC: C12N1/20 ; C12P13/04 ; C12N15/00 ; C12P13/08 ; C12N9/88 ; C12P13/06 ; C12N9/10
Abstract:
A mutant bacterial acetolactate synthase (AHAS I) which is resistant to feedback inhibition by L-valine is described. Also described is a method for producing branched-chain L-amino acids using a bacterium from the Enterobacteriaceae family wherein the L-amino acid productivity of said bacterium is enhanced by the use of the acetolactate synthase (AHAS I) which is resistant to feedback inhibition by L-valine. This acetolactate synthase contains a mutant small subunit encoded by the mutant ilvN gene.
Public/Granted literature
- US20140335574A1 Mutant Acetolactate Synthase and a Method for Producing Branched-Chain L-Amino Acids Public/Granted day:2014-11-13
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