Invention Grant
- Patent Title: Screening method for BRAF inhibitors
- Patent Title (中): BRAF抑制剂的筛选方法
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Application No.: US14096954Application Date: 2013-12-04
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Publication No.: US09279144B2Publication Date: 2016-03-08
- Inventor: Levi Garraway , Caroline Emery
- Applicant: DANA-FARBER CANCER INSTITUTE, INC.
- Applicant Address: US MA Boston
- Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee Address: US MA Boston
- Agency: Brinks Gilson & Lione
- Main IPC: G01N33/53
- IPC: G01N33/53 ; A61P35/00 ; C12Q1/48 ; A61K31/4184 ; A61K31/5377 ; C12N9/12 ; A61K31/437 ; A61K31/4439 ; G01N33/573
Abstract:
The present invention relates to methods, compositions and kits concerning resistance to treatment with an anti-cancer agent, specifically an inhibitor of BRAF. In particular embodiments, the invention concerns mutations in a BRAF sequence that confer resistance to a BRAF inhibitor. Identification of such mutations in a BRAF sequence allows the identification and design of second-generation BRAF inhibitors. Methods and kits for detecting the presence of a mutant BRAF sequence in a sample are also provided.
Public/Granted literature
- US20140155399A1 BRAF Mutations Conferring Resistance to BRAF Inhibitors Public/Granted day:2014-06-05
Information query
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