Invention Grant
US09279146B2 Compounds and methods for the enrichment of mutated nucleic acid from a mixture
有权
用于从混合物中富集突变的核酸的化合物和方法
- Patent Title: Compounds and methods for the enrichment of mutated nucleic acid from a mixture
- Patent Title (中): 用于从混合物中富集突变的核酸的化合物和方法
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Application No.: US14098789Application Date: 2013-12-06
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Publication No.: US09279146B2Publication Date: 2016-03-08
- Inventor: Amar Gupta , Nancy Schoenbrunner
- Applicant: Roche Molecular Systems, Inc.
- Applicant Address: US CA Pleasanton
- Assignee: ROCHE MOLECULAR SYSTEMS, INC.
- Current Assignee: ROCHE MOLECULAR SYSTEMS, INC.
- Current Assignee Address: US CA Pleasanton
- Agent David J Chang
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C07F15/00
Abstract:
The detection of the presence of rare somatic mutations from a biological sample is often challenging due to the simultaneous presence of a vast excess of wild-type DNA. The present invention describes novel compounds and methods that would allow the enrichment of mutant DNA by depleting amplifiable wild-type DNA.
Public/Granted literature
- US20140308664A1 Compounds and Methods for the Enrichment of Mutated Nucleic Acid from a Mixture Public/Granted day:2014-10-16
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