Invention Grant
US09279161B2 Monoclonal antibody recognizing human papillomavirus (HPV) L2 protein and method for measuring HPV-neutralizing antibody titer using the same
有权
识别人乳头状瘤病毒（HPV）L2蛋白的单克隆抗体及使用该蛋白测定HPV中和抗体滴度的方法
- Patent Title: Monoclonal antibody recognizing human papillomavirus (HPV) L2 protein and method for measuring HPV-neutralizing antibody titer using the same
- Patent Title (中): 识别人乳头状瘤病毒（HPV）L2蛋白的单克隆抗体及使用该蛋白测定HPV中和抗体滴度的方法
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Application No.: US13997902Application Date: 2011-12-26
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Publication No.: US09279161B2Publication Date: 2016-03-08
- Inventor: Seiichiro Mori , Tadahito Kanda
- Applicant: Seiichiro Mori , Tadahito Kanda
- Applicant Address: JP Tokyo
- Assignee: Japan Health Sciences Foundation
- Current Assignee: Japan Health Sciences Foundation
- Current Assignee Address: JP Tokyo
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Agent David G. Conlin, Esq.; Daniel W. Clarke
- Priority: JP2010-291067 20101227
- International Application: PCT/JP2011/079994 WO 20111226
- International Announcement: WO2012/090895 WO 20120705
- Main IPC: A61K39/42
- IPC: A61K39/42 ; C12Q1/70 ; C07K16/08 ; G01N33/574 ; A61K47/48 ; G01N33/569 ; A61K39/12 ; A61K39/00
Abstract:
The present invention relates to the development of a monoclonal antibody which has binding activity to many high-risk types of HPV, etc. The present invention also provides a simple and high-throughput method for measuring cross-neutralizing antibody titers, which is used for assay of cross-neutralizing antibody against HPV in serum samples from subjects, etc. The method of the present invention for measuring cross-neutralizing antibody titers comprises the steps of: preparing a monoclonal antibody against a peptide having a specific amino acid sequence common to high-risk types of HPV; and assaying cross-neutralizing antibody using this monoclonal antibody.
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