An LED lighting ball structure includes a spherical shell, a control unit and a plurality of LED lighting units. The spherical shell includes a first segment and a second segment coupled with the first segment to jointly define a housing space. The first segment includes a first housing portion and a first decorative cover plate coupled with the first housing portion. The first housing portion includes a plurality of first assembly holes communicating with the housing space. The second segment includes a second housing portion and a second decorative cover plate coupled with the second housing portion. The second housing portion includes a plurality of second assembly holes communicating with the housing space. The control unit is located in the housing space. The LED lighting units are located in the first and second assembly holes respectively and form electrical connection with the control unit.