Invention Grant
- Patent Title: Proteins that efficiently generate singlet oxygen
- Patent Title (中): 有效产生单线态氧的蛋白质
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Application No.: US13992540Application Date: 2011-12-07
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Publication No.: US09279769B2Publication Date: 2016-03-08
- Inventor: Xiaokun Shu , Roger Y. Tsien
- Applicant: Xiaokun Shu , Roger Y. Tsien
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Morgan, Lewis & Bockius LLP
- International Application: PCT/US2011/063841 WO 20111207
- International Announcement: WO2012/078816 WO 20120614
- Main IPC: C07K14/00
- IPC: C07K14/00 ; G01N21/64 ; C12N9/12
Abstract:
The present invention provides miniSOG proteins, polynucleotides, and methods of use. When expressed in a bacterial or mammalian cell, miniSOG proteins spontaneously incorporate flavin mononucleotide and produce fluorescence and singlet oxygen upon excitation. Uses include optical and electron microscope imaging, in vivo imaging, detection and localization of protein-protein interactions, and photoablation.
Public/Granted literature
- US20130330718A1 PROTEINS THAT EFFICIENTLY GENERATE SINGLET OXYGEN Public/Granted day:2013-12-12
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