Invention Grant
- Patent Title: Solid state synthesis hydroxyl radicals for high throughput structure determination of proteins and nucleic acids by oxidative footprinting
- Patent Title (中): 固态合成羟基自由基用于通过氧化足迹测定蛋白质和核酸的高通量结构
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Application No.: US13063833Application Date: 2009-08-24
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Publication No.: US09279814B2Publication Date: 2016-03-08
- Inventor: Michael Brenowitz , Jorg Schlatterer
- Applicant: Michael Brenowitz , Jorg Schlatterer
- Applicant Address: US NY Bronx
- Assignee: Albert Einstein College of Medicine, Inc.
- Current Assignee: Albert Einstein College of Medicine, Inc.
- Current Assignee Address: US NY Bronx
- Agency: Amster, Rothstein & Ebenstein LLP
- International Application: PCT/US2009/004804 WO 20090824
- International Announcement: WO2010/030321 WO 20100318
- Main IPC: G01N33/68
- IPC: G01N33/68 ; B01L3/00 ; C07H21/00
Abstract:
The present invention generally relates to an apparatus for structural mapping of a macromolecule comprising an amount of persulfide effective to generate hydroxyl radicals upon contact with an aqueous solution. The present invention further relates to methods for structural mapping a macromolecule in an aqueous solution and methods for structural mapping a plurality of macromolecules in parallel, wherein each macromolecule is in a separate aqueous solution.
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