A method, an apparatus, and a computer readable medium for polygon gesture detection and interaction, adapted to an electronic apparatus having an input unit, are provided. In the method, a gesture moving from a starting point to an end point is received by using the input unit and sampling points thereof are collected. A trajectory of the sampling points is analyzed to obtain a center of the gesture. A surrounding area of the center is divided into equal label areas. A distance and an angle relative to an origin of each sampling point in the label areas are calculated and used as a vertical axis and a horizontal axis to draw a waveform diagram. A shape formed by the trajectory is determined according to characteristics of the waveform diagram and a specific function corresponding to the shape is performed.