Systems and methods of scheduling and sending notifications to, and receiving acknowledgements from, patients regarding specific health care events, such as the taking of medications at scheduled times and in prescribed dosages. By directing a patient to take their prescribed dosages of medication at scheduled times based on a schedule of medications prepared for the patient by a health care provider, a caregiver, etc., and enabling the patient to provide acknowledgements of having taken their prescribed dosages of medication, improved health care outcomes can be achieved. Further, by allowing the patient to receive such directives to take their medication, as well as to send such acknowledgements, using a set top box connected to a television set, a mobile device such as a mobile phone, and/or a patient notification device such as a wireless pendant, desired improvements in health care outcomes can be achieved with an increased level of convenience.