A tool for targeting a message response. The tool monitors reactions of a user to message subject lines, message content, and social networks. The tool analyzes user interest data and calculates a user interest rating per keyword. Rated keywords are stored in association with the user. When a user drafts a message addressed to a recipient, the tool compares rated keywords within the recipient's log with the subject line and message content. The tool suggests an alternative subject line likely to elicit a faster and more detailed response from the recipient.