Systems and methods for channel-dependent CCA thresholds to balance different use cases in wireless networks are disclosed. In one aspect a device includes a receiver configured to receive transmissions on a plurality of channels. The device also includes a processor configured to determine whether a channel is one at least a first type or a second type of channel. If the channel is the first type, the processor is configured to determine whether the channel is available based at least in part on a set of first clear channel assessment thresholds. If the channel is the second type, the processor is configured to determine whether the channel is available based at least in part on a set of second clear channel assessment thresholds, where the set of second clear channel assessment thresholds is greater than or equal to the set of first clear channel assessment thresholds.