A system for processing signals may be configured to apply digital conversion to analog signals, and to apply, prior to the analog-to-digital conversion, a gain to at least a portion of the analog signals. The gain may be controlled and/or adjusted based on processing of digital output generated based on the analog-to-digital conversion. The system may comprise a plurality of sampling slices, which may be configured to provide the analog-to-digital conversion in interleaved (e.g., time-interleaved) manner. Each of the sampling slices may comprise a dedicated gain element, for applying gain to signals handled by the corresponding slice. The gain applied by the gain elements of the sampling slices may be controlled, independently, collectively, and/or in based on grouping into subsets. The gain may be controlled based on application of a particular gain control algorithm, which may be selected from a plurality of predefined algorithms.