A method, a base station and a system for managing resources belong to the field of communication technologies. In an embodiment of the present invention, the base station decodes the uplink data or the acknowledgement information sent by the user equipment according to the format of the periodic indication information comprised in the uplink data or the acknowledgement information, determines that the uplink data or the acknowledgement information sent by the user equipment comprises the periodic indication information when the decoding is successful, and then validates the periodic resources corresponding to the periodic indication information comprised in the uplink data or the acknowledgement information. The technical solution of the present invention overcomes the problem in the prior art that data is erroneously retransmitted since the base station and the user equipment asynchronously validate the periodic resources corresponding to the periodic indication information, thereby reducing interruption time delay.