Invention Grant
- Patent Title: Methods for inhibiting redox-sensitive GTPases
- Patent Title (中): 抑制氧化还原敏感性GTP酶的方法
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Application No.: US14227712Application Date: 2014-03-27
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Publication No.: US09301960B2Publication Date: 2016-04-05
- Inventor: Jongyun Heo
- Applicant: Jongyun Heo
- Applicant Address: US TX Austin
- Assignee: Board of Regents, The University of Texas Systems
- Current Assignee: Board of Regents, The University of Texas Systems
- Current Assignee Address: US TX Austin
- Agency: Nevrivy Patent Law Group P.L.L.C.
- Main IPC: A61K31/70
- IPC: A61K31/70 ; A61K31/52 ; A61K31/522 ; A61K33/00 ; A61K33/40 ; A61K45/06 ; C12Q1/34 ; A61K31/15
Abstract:
The invention provides compositions for inhibiting a redox-sensitive GTPase protein, including a Rho or Rab family GTPase, comprising an effective amount of a redox-sensitive purine compound and an effective amount of a redox agent. The invention further provides methods of inhibiting a redox-sensitive GTPase protein, including a Rho or Rab family GTPase, by administering compositions of the invention. Methods of screening for compounds that inhibit a redox-sensitive GTPase protein, including compounds that target and inhibit Rho or Rab family GTPases, are further provided.
Public/Granted literature
- US20140200230A1 COMPOSITIONS AND METHODS FOR INHIBITING REDOX-SENSITIVE GTPASES Public/Granted day:2014-07-17
Information query
